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The physiology and habitat of the last universal common ancestor

Overview of attention for article published in Nature Microbiology, January 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 671)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
105 news outlets
blogs
18 blogs
twitter
306 tweeters
peer_reviews
1 peer review site
facebook
14 Facebook pages
wikipedia
5 Wikipedia pages
googleplus
10 Google+ users
reddit
1 Redditor
video
3 video uploaders

Citations

dimensions_citation
147 Dimensions

Readers on

mendeley
573 Mendeley
citeulike
3 CiteULike
Title
The physiology and habitat of the last universal common ancestor
Published in
Nature Microbiology, January 2016
DOI 10.1038/nmicrobiol.2016.116
Pubmed ID
Authors

Madeline C. Weiss, Filipa L. Sousa, Natalia Mrnjavac, Sinje Neukirchen, Mayo Roettger, Shijulal Nelson-Sathi, William F. Martin, Weiss, Madeline C, Sousa, Filipa L, Mrnjavac, Natalia, Neukirchen, Sinje, Roettger, Mayo, Nelson-Sathi, Shijulal, Martin, William F

Abstract

The concept of a last universal common ancestor of all cells (LUCA, or the progenote) is central to the study of early evolution and life's origin, yet information about how and where LUCA lived is lacking. We investigated all clusters and phylogenetic trees for 6.1 million protein coding genes from sequenced prokaryotic genomes in order to reconstruct the microbial ecology of LUCA. Among 286,514 protein clusters, we identified 355 protein families (∼0.1%) that trace to LUCA by phylogenetic criteria. Because these proteins are not universally distributed, they can shed light on LUCA's physiology. Their functions, properties and prosthetic groups depict LUCA as anaerobic, CO2-fixing, H2-dependent with a Wood-Ljungdahl pathway, N2-fixing and thermophilic. LUCA's biochemistry was replete with FeS clusters and radical reaction mechanisms. Its cofactors reveal dependence upon transition metals, flavins, S-adenosyl methionine, coenzyme A, ferredoxin, molybdopterin, corrins and selenium. Its genetic code required nucleoside modifications and S-adenosyl methionine-dependent methylations. The 355 phylogenies identify clostridia and methanogens, whose modern lifestyles resemble that of LUCA, as basal among their respective domains. LUCA inhabited a geochemically active environment rich in H2, CO2 and iron. The data support the theory of an autotrophic origin of life involving the Wood-Ljungdahl pathway in a hydrothermal setting.

Twitter Demographics

The data shown below were collected from the profiles of 306 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 573 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 8 1%
United States 8 1%
United Kingdom 7 1%
France 5 <1%
Canada 4 <1%
Spain 3 <1%
Australia 2 <1%
Brazil 2 <1%
Netherlands 2 <1%
Other 12 2%
Unknown 520 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 149 26%
Researcher 108 19%
Student > Bachelor 96 17%
Student > Master 73 13%
Unspecified 35 6%
Other 111 19%
Unknown 1 <1%
Readers by discipline Count As %
Agricultural and Biological Sciences 215 38%
Biochemistry, Genetics and Molecular Biology 123 21%
Unspecified 55 10%
Earth and Planetary Sciences 44 8%
Environmental Science 30 5%
Other 105 18%
Unknown 1 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 1151. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2018.
All research outputs
#2,112
of 11,787,076 outputs
Outputs from Nature Microbiology
#3
of 671 outputs
Outputs of similar age
#129
of 266,148 outputs
Outputs of similar age from Nature Microbiology
#2
of 72 outputs
Altmetric has tracked 11,787,076 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 671 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 69.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,148 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.