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Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells

Overview of attention for article published in Genome Biology (Online Edition), July 2016
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  • Good Attention Score compared to outputs of the same age (65th percentile)

Mentioned by

twitter
7 tweeters

Citations

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37 Dimensions

Readers on

mendeley
34 Mendeley
citeulike
1 CiteULike
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Title
Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells
Published in
Genome Biology (Online Edition), July 2016
DOI 10.1186/s13059-016-1023-z
Pubmed ID
Authors

Xiao-Li Zhang, Jun Wu, Jian Wang, Tingting Shen, Hua Li, Jun Lu, Yunzhao Gu, Yani Kang, Chee-Hong Wong, Chew Yee Ngan, Zhifeng Shao, Ji Wu, Xiaodong Zhao

Abstract

Germline stem cells play an essential role in establishing the fertility of an organism. Although extensively characterized, the regulatory mechanisms that govern the fundamental properties of mammalian female germline stem cells remain poorly understood. We generate genome-wide profiles of the histone modifications H3K4me1, H3K27ac, H3K4me3, and H3K27me3, DNA methylation, and RNA polymerase II occupancy and perform transcriptome analysis in mouse female germline stem cells. Comparison of enhancer regions between embryonic stem cells and female germline stem cells identifies the lineage-specific enhancers involved in germline stem cell features. Additionally, our results indicate that DNA methylation primarily contributes to female germline stem cell unipotency by suppressing the somatic program and is potentially involved in maintenance of sexual identity when compared with male germline stem cells. Moreover, we demonstrate down-regulation of Prmt5 triggers differentiation and thus uncover a role for Prmt5 in maintaining the undifferentiated status of female germline stem cells. The genome-wide epigenetic signatures and the transcription regulators identified here provide an invaluable resource for understanding the fundamental features of mouse female germline stem cells.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 6 18%
Other 4 12%
Professor 4 12%
Student > Master 4 12%
Other 6 18%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 41%
Biochemistry, Genetics and Molecular Biology 14 41%
Unspecified 1 3%
Decision Sciences 1 3%
Engineering 1 3%
Other 0 0%
Unknown 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
#2,060,840
of 8,154,593 outputs
Outputs from Genome Biology (Online Edition)
#1,625
of 2,334 outputs
Outputs of similar age
#83,788
of 257,935 outputs
Outputs of similar age from Genome Biology (Online Edition)
#48
of 58 outputs
Altmetric has tracked 8,154,593 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 2,334 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,935 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.