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DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster

Overview of attention for article published in Genetics and Molecular Biology, July 2016
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Title
DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster
Published in
Genetics and Molecular Biology, July 2016
DOI 10.1590/1678-4685-gmb-2015-0129
Pubmed ID
Authors

Silva, Robson Alves da, Dihl, Rafael Rodrigues, Dias, Lucas Pinheiro, Costa, Maiane Papke, Abreu, Bianca Regina Ribas de, Cunha, Kênya Silva, Lehmann, Mauricio

Abstract

Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with the wing spot test in Drosophila melanogaster using co- and post-treatment protocols. Additionally, the antimutagenic activity of two HSCAN components, cashew apple pulp and honey, in MMC-induced DNA damage was also investigated. HSCAN reduced the mutagenic activity of both EMS and MMC in the co-treatment protocol, but had a co-mutagenic effect when post-administered. Similar results were also observed with honey on MMC mutagenic activity. Cashew apple pulp was effective in exerting protective or enhancing effects on the MMC mutagenicity, depending on the administration protocol and concentration used. Overall, these results indicate that HSCAN, cashew apple and honey seem capable of modulating not only the events that precede the induced DNA damages, but also the Drosophila DNA repair processes involved in the correction of EMS and MMC-induced damages.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Student > Master 3 17%
Student > Ph. D. Student 2 11%
Lecturer > Senior Lecturer 1 6%
Researcher 1 6%
Other 0 0%
Unknown 7 39%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 33%
Nursing and Health Professions 1 6%
Agricultural and Biological Sciences 1 6%
Immunology and Microbiology 1 6%
Chemistry 1 6%
Other 0 0%
Unknown 8 44%