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Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa

Overview of attention for article published in Genetics, September 2016
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)

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5 tweeters
1 Facebook page


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Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Corepressor of Neurospora crassa
Published in
Genetics, September 2016
DOI 10.1534/genetics.116.191064
Pubmed ID

Consuelo Olivares-Yañez, Jillian Emerson, Arminja Kettenbach, Jennifer J Loros, Jay C Dunlap, Luis F Larrondo


Neurospora crassa is a model organism for the study of circadian clocks, molecular machineries that confer circa 24 h rhythms to different processes at the cellular and organismal level. The FREQUENCY (FRQ) protein is a central component of the Neurospora core-clock, a transcription-translation negative feedback loop that controls genome-wide rhythmic gene expression. A genetic screen aimed at determining new components involved in the latter process identified rco-1 (regulation of conidiation-1), the ortholog of the Saccharomyces cerevisiae Tup1 co-repressor, as affecting period length. By employing bioluminescent transcriptional and translational fusion reporters we evaluated frq and FRQ expression levels in the rco-1 mutant background observing that, in contrast to prior reports, frq and FRQ expression are robustly rhythmic in the absence of RCO-1 although both amplitude and period length of the core-clock are affected. Moreover, we detected a defect in metabolic compensation, such that high-glucose concentrations in the medium result in a significant decrease in period when RCO-1 is absent. Proteins physically interacting with RCO-1 were identified through co-immunoprecipitation and mass-spectrometry; these include several components involved in chromatin remodeling and transcription, some of which, when absent, lead to a slight change in period. In the aggregate, these results indicate a dual role for RCO-1: although it is not essential for core-clock function, it regulates proper period and amplitude of core-clock dynamics, and is also required for the rhythmic regulation of several clock-controlled genes.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 28%
Researcher 7 19%
Student > Doctoral Student 3 8%
Student > Master 3 8%
Student > Bachelor 2 6%
Other 5 14%
Unknown 6 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 42%
Agricultural and Biological Sciences 10 28%
Psychology 1 3%
Energy 1 3%
Unknown 9 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2017.
All research outputs
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Outputs from Genetics
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Outputs of similar age
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Outputs of similar age from Genetics
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Altmetric has tracked 16,610,725 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,228 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.