Title |
Antimicrobial nodule-specific cysteine-rich peptides disturb the integrity of bacterial outer and inner membranes and cause loss of membrane potential
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Published in |
Annals of Clinical Microbiology and Antimicrobials, July 2016
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DOI | 10.1186/s12941-016-0159-8 |
Pubmed ID | |
Authors |
Kata R. Mikuláss, Krisztina Nagy, Balázs Bogos, Zsolt Szegletes, Etelka Kovács, Attila Farkas, György Váró, Éva Kondorosi, Attila Kereszt |
Abstract |
Certain legume plants produce a plethora of AMP-like peptides in their symbiotic cells. The cationic subgroup of the nodule-specific cysteine-rich (NCR) peptides has potent antimicrobial activity against gram-negative and gram-positive bacteria as well as unicellular and filamentous fungi. It was shown by scanning and atomic force microscopies that the cationic peptides NCR335, NCR247 and Polymyxin B (PMB) affect differentially on the surfaces of Sinorhizobium meliloti bacteria. Similarly to PMB, both NCR peptides caused damages of the outer and inner membranes but at different extent and resulted in the loss of membrane potential that could be the primary reason of their antimicrobial activity. The primary reason for bacterial cell death upon treatment with cationic NCR peptides is the loss of membrane potential. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 2 | 50% |
Brazil | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 24% |
Researcher | 10 | 17% |
Student > Bachelor | 7 | 12% |
Student > Master | 6 | 10% |
Other | 3 | 5% |
Other | 4 | 7% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 39% |
Biochemistry, Genetics and Molecular Biology | 14 | 24% |
Unspecified | 1 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Chemical Engineering | 1 | 2% |
Other | 3 | 5% |
Unknown | 16 | 27% |