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Epigenetic dynamics of monocyte-to-macrophage differentiation

Overview of attention for article published in Epigenetics & Chromatin, July 2016
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  • Good Attention Score compared to outputs of the same age (72nd percentile)

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Title
Epigenetic dynamics of monocyte-to-macrophage differentiation
Published in
Epigenetics & Chromatin, July 2016
DOI 10.1186/s13072-016-0079-z
Pubmed ID
Authors

Stefan Wallner, Christopher Schröder, Elsa Leitão, Tea Berulava, Claudia Haak, Daniela Beißer, Sven Rahmann, Andreas S. Richter, Thomas Manke, Ulrike Bönisch, Laura Arrigoni, Sebastian Fröhler, Filippos Klironomos, Wei Chen, Nikolaus Rajewsky, Fabian Müller, Peter Ebert, Thomas Lengauer, Matthias Barann, Philip Rosenstiel, Gilles Gasparoni, Karl Nordström, Jörn Walter, Benedikt Brors, Gideon Zipprich, Bärbel Felder, Ludger Klein-Hitpass, Corinna Attenberger, Gerd Schmitz, Bernhard Horsthemke

Abstract

Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to analyze the complete transcriptome and epigenome of human monocytes that were differentiated in vitro by addition of colony-stimulating factor 1 in serum-free medium. Numerous mRNAs and miRNAs were significantly up- or down-regulated. More than 100 discrete DNA regions, most often far away from transcription start sites, were rapidly demethylated by the ten eleven translocation enzymes, became nucleosome-free and gained histone marks indicative of active enhancers. These regions were unique for macrophages and associated with genes involved in the regulation of the actin cytoskeleton, phagocytosis and innate immune response. In summary, we have discovered a phagocytic gene network that is repressed by DNA methylation in monocytes and rapidly de-repressed after the onset of macrophage differentiation.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Korea, Republic of 1 <1%
Unknown 188 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 38 20%
Student > Ph. D. Student 34 18%
Student > Postgraduate 29 15%
Student > Master 22 12%
Student > Bachelor 19 10%
Other 23 12%
Unknown 26 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 73 38%
Agricultural and Biological Sciences 42 22%
Immunology and Microbiology 20 10%
Medicine and Dentistry 12 6%
Neuroscience 3 2%
Other 10 5%
Unknown 31 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2016.
All research outputs
#5,905,662
of 22,881,964 outputs
Outputs from Epigenetics & Chromatin
#230
of 568 outputs
Outputs of similar age
#100,819
of 365,421 outputs
Outputs of similar age from Epigenetics & Chromatin
#13
of 15 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 568 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,421 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.