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Attention Score in Context
| Title |
Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson’s disease
|
|---|---|
| Published in |
Scientific Reports, July 2016
|
| DOI | 10.1038/srep30424 |
| Pubmed ID | |
| Authors |
Rwei-Ling Yu, Chun-Hsiang Tan, Ying-Che Lu, Ruey-Meei Wu |
| Abstract |
Neurotransmitter degradation has been proposed to cause the accumulation of neurotoxic metabolites. The metabolism of these metabolites involves aldehyde dehydrogenase 2 (ALDH2). The Asian-specific single nucleotide polymorphism rs671 causes reduced enzyme activity. This study aims to explore whether Parkinson's disease (PD) patients with reduced ALDH2 activity owing to the rs671 polymorphism are at risk for neuropsychological impairments. A total of 139 PD patients were recruited. Each participant was assessed for medical characteristics and their ALDH2 genotype. The Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Scale and the Frontal Behavioral Inventory were used to measure neuropsychological functions. We found that the MMSE scores were significantly lower in patients with inactive ALDH2 (U = 1873.5, p = 0.02). The presence of cognitive impairments was significantly more frequent in the inactive ALDH2 group (46.0%) than in the active ALDH2 group (26.3%) (χ(2) = 5.886, p = 0.01). The inactive group showed significant deterioration in hobbies and exhibited more severe "disorganization" and "hyper-sexuality" behaviours. The additive effects of the allele on the development of cognitive impairments in PD patients may be an important finding that provides further insight into the pathogenic mechanism of cognitive dysfunction in PD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 16% |
| Student > Ph. D. Student | 6 | 13% |
| Student > Bachelor | 4 | 9% |
| Researcher | 4 | 9% |
| Other | 4 | 9% |
| Other | 5 | 11% |
| Unknown | 15 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 11% |
| Medicine and Dentistry | 5 | 11% |
| Psychology | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Computer Science | 2 | 4% |
| Other | 10 | 22% |
| Unknown | 16 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2017.
All research outputs
#3,209,371
of 22,881,964 outputs
Outputs from Scientific Reports
#27,499
of 123,614 outputs
Outputs of similar age
#61,597
of 365,443 outputs
Outputs of similar age from Scientific Reports
#770
of 3,619 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,614 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,443 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 3,619 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.