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Anti cancer effects of curcumin: cycle of life and death

Overview of attention for article published in Cell Division, October 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

blogs
1 blog
twitter
7 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user
pinterest
1 Pinner

Citations

dimensions_citation
196 Dimensions

Readers on

mendeley
201 Mendeley
citeulike
1 CiteULike
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Title
Anti cancer effects of curcumin: cycle of life and death
Published in
Cell Division, October 2008
DOI 10.1186/1747-1028-3-14
Pubmed ID
Authors

Gaurisankar Sa, Tanya Das

Abstract

Increasing knowledge on the cell cycle deregulations in cancers has promoted the introduction of phytochemicals, which can either modulate signaling pathways leading to cell cycle regulation or directly alter cell cycle regulatory molecules, in cancer therapy. Most human malignancies are driven by chromosomal translocations or other genetic alterations that directly affect the function of critical cell cycle proteins such as cyclins as well as tumor suppressors, e.g., p53. In this respect, cell cycle regulation and its modulation by curcumin are gaining widespread attention in recent years. Extensive research has addressed the chemotherapeutic potential of curcumin (diferuloylmethane), a relatively non-toxic plant derived polyphenol. The mechanisms implicated are diverse and appear to involve a combination of cell signaling pathways at multiple levels. In the present review we discuss how alterations in the cell cycle control contribute to the malignant transformation and provide an overview of how curcumin targets cell cycle regulatory molecules to assert anti-proliferative and/or apoptotic effects in cancer cells. The purpose of the current article is to present an appraisal of the current level of knowledge regarding the potential of curcumin as an agent for the chemoprevention of cancer via an understanding of its mechanism of action at the level of cell cycle regulation. Taken together, this review seeks to summarize the unique properties of curcumin that may be exploited for successful clinical cancer prevention.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 2 <1%
United States 2 <1%
India 2 <1%
Brazil 1 <1%
Australia 1 <1%
Italy 1 <1%
Iran, Islamic Republic of 1 <1%
Japan 1 <1%
Malaysia 1 <1%
Other 1 <1%
Unknown 188 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 25%
Student > Master 40 20%
Student > Bachelor 31 15%
Researcher 17 8%
Lecturer 9 4%
Other 36 18%
Unknown 18 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 28%
Biochemistry, Genetics and Molecular Biology 33 16%
Medicine and Dentistry 30 15%
Pharmacology, Toxicology and Pharmaceutical Science 17 8%
Chemistry 14 7%
Other 26 13%
Unknown 25 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2017.
All research outputs
#1,081,309
of 13,330,378 outputs
Outputs from Cell Division
#2
of 85 outputs
Outputs of similar age
#11,591
of 146,476 outputs
Outputs of similar age from Cell Division
#1
of 3 outputs
Altmetric has tracked 13,330,378 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,476 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them