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Association between levobupivacaine and pancuronium. Interference in neuromuscular transmission and blockade in rats

Overview of attention for article published in Acta Cirurgica Brasileira, July 2016
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Title
Association between levobupivacaine and pancuronium. Interference in neuromuscular transmission and blockade in rats
Published in
Acta Cirurgica Brasileira, July 2016
DOI 10.1590/s0102-865020160070000009
Pubmed ID
Authors

Vanessa Henriques Carvalho, Angélica de Fátima de Assunção Braga, Franklin Sarmento da Silva Braga, Gloria Maria Braga Potério, Filipe Nadir Caparica Santos, Fernando Eduardo Féres Junqueira

Abstract

To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 µg.mL-1); Group II - pancuronium (2 µg.mL-1); Group III - pancuronium (2 µg.mL-1) + levobupivacaine (5µg.mL-1). The following parameters were evaluated: 1) amplitude of diaphragmatic response to indirect stimulation, before and 60 minutes after the addition of levobupivacaine and pancuronium alone, and after the addition of levobupivacaine combined with pancuronium; 2) membrane potentials (MP) and miniature endplate potentials (MEPP). Levobupivacaine alone did not alter the amplitude of muscle response and MP. In preparations previoulsy exposed to levobupivacaine, the block with pancuronium was significantly denser (90.2 ± 15.2%), showing a significant difference (p=0.031) in comparison to the block produced by pancuronium alone (48.9% ± 9.8%). There was a decrease in the frequency and amplitude of MEPPs. Levobupivacaine potentiated the neuromuscular blockade produced by pancuronium, confirming a presynaptic action by a decrease in miniature endplate potentials.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 25%
Lecturer > Senior Lecturer 1 13%
Professor 1 13%
Unknown 4 50%
Readers by discipline Count As %
Medicine and Dentistry 2 25%
Neuroscience 1 13%
Sports and Recreations 1 13%
Unknown 4 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2016.
All research outputs
#11,975,651
of 13,508,992 outputs
Outputs from Acta Cirurgica Brasileira
#102
of 141 outputs
Outputs of similar age
#223,326
of 266,040 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#1
of 3 outputs
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So far Altmetric has tracked 141 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them