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Genetic and pathogenic difference between Streptococcus agalactiae serotype Ia fish and human isolates

Overview of attention for article published in BMC Microbiology, August 2016
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Title
Genetic and pathogenic difference between Streptococcus agalactiae serotype Ia fish and human isolates
Published in
BMC Microbiology, August 2016
DOI 10.1186/s12866-016-0794-4
Pubmed ID
Authors

Chishih Chu, Pei-Yu Huang, Hung-Ming Chen, Ying-Hsiang Wang, I-An Tsai, Chih-Cheng Lu, Che-Chun Chen

Abstract

Streptococcus agalactiae (GBS) is a common pathogen to infect newborn, woman, the elderly, and immuno-compromised human and fish. 37 fish isolates and 554 human isolates of the GBS in 2007-2012 were investigated in serotypes, antibiotic susceptibility, genetic difference and pathogenicity to tilapia. PCR serotyping determined serotype Ia for all fish GBS isolates and only in 3.2 % (3-4.2 %) human isolates. For fish isolates, all consisted a plasmid less than 6 kb and belonged to ST7 type, which includes mainly pulsotypes I and Ia, with a difference in a deletion at the largest DNA fragment. These fish isolates were susceptible to all antimicrobials tested in 2007 and increased in non-susceptibility to penicillin, and resistance to clindamycin and ceftriaxone in 2011. Differing in pulsotype and lacking plasmid from fish isolates, human serotype Ia isolates were separated into eight pulsotypes II-IX. Main clone ST23 included pulsotypes II and IIa (50 %) and ST483 consisted of pulsotype III. Human serotype Ia isolates were all susceptible to ceftriaxone and penicillin and few were resistant to erythromycin, azithromycin, clindamycin, levofloxacin and moxifloxacine with the resistant rate of 20 % or less. Using tilapia to analyze the pathogenesis, fish isolates could cause more severe symptoms, including hemorrhage of the pectoral fin, hemorrhage of the gill, and viscous black and common scites, and mortality (>95 % for pulsotype I) than the human isolates (<30 %); however, the fish pulostype Ia isolate 912 with deletion caused less symptoms and the lowest mortality (<50 %) than pulsotype I isolates. Genetic, pathogenic, and antimicrobial differences demonstrate diverse origin of human and fish serotype Ia isolates. The pulsotype Ia of fish serotype Ia isolates may be used as vaccine strains to prevent the GBS infection in fish.

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Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 22%
Researcher 4 13%
Student > Ph. D. Student 3 9%
Student > Postgraduate 2 6%
Student > Bachelor 2 6%
Other 4 13%
Unknown 10 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 44%
Medicine and Dentistry 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Veterinary Science and Veterinary Medicine 2 6%
Chemical Engineering 1 3%
Other 0 0%
Unknown 10 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2016.
All research outputs
#7,068,062
of 8,166,192 outputs
Outputs from BMC Microbiology
#1,102
of 1,364 outputs
Outputs of similar age
#217,623
of 257,711 outputs
Outputs of similar age from BMC Microbiology
#78
of 93 outputs
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So far Altmetric has tracked 1,364 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.