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New insights into signalling networks regulating breast cancer stem cells

Overview of attention for article published in Breast Cancer Research, January 2012
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Title
New insights into signalling networks regulating breast cancer stem cells
Published in
Breast Cancer Research, January 2012
DOI 10.1186/bcr3209
Pubmed ID
Authors

Swarbrick, Alexander, Daly, Roger J

Abstract

In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 10%
Australia 1 10%
Unknown 8 80%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 60%
Student > Ph. D. Student 2 20%
Student > Postgraduate 2 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 80%
Medicine and Dentistry 2 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2012.
All research outputs
#13,234,576
of 14,976,421 outputs
Outputs from Breast Cancer Research
#1,476
of 1,608 outputs
Outputs of similar age
#131,627
of 152,509 outputs
Outputs of similar age from Breast Cancer Research
#33
of 41 outputs
Altmetric has tracked 14,976,421 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,608 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,509 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.