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Reactive oxygen species in organ-specific autoimmunity

Overview of attention for article published in Autoimmunity Highlights, August 2016
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1 tweeter
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1 Facebook page

Citations

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22 Dimensions

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53 Mendeley
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Title
Reactive oxygen species in organ-specific autoimmunity
Published in
Autoimmunity Highlights, August 2016
DOI 10.1007/s13317-016-0083-0
Pubmed ID
Authors

Giulia Di Dalmazi, Jason Hirshberg, Daniel Lyle, Joudeh B. Freij, Patrizio Caturegli

Abstract

Reactive oxygen species (ROS) have been extensively studied in the induction of inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS have been implicated in the pathogenesis of autoimmune diseases. Here, ROS accumulation leads to apoptosis and autoantigen structural changes that result in novel specificities. ROS have been implicated not only in the initiation of the autoimmune response but also in its amplification and spreading to novel epitopes, through the unmasking of cryptic determinants. This review will examine the contribution of ROS to the pathogenesis of four organ specific autoimmune diseases (Hashimoto thyroiditis, inflammatory bowel disease, multiple sclerosis, and vitiligo), and compare it to that of a better characterized systemic autoimmune disease (rheumatoid arthritis). It will also discuss tobacco smoking as an environmental factor endowed with both pro-oxidant and anti-oxidant properties, thus capable of differentially modulating the autoimmune response.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 17%
Student > Ph. D. Student 8 15%
Researcher 8 15%
Student > Master 7 13%
Student > Postgraduate 6 11%
Other 11 21%
Unknown 4 8%
Readers by discipline Count As %
Medicine and Dentistry 14 26%
Biochemistry, Genetics and Molecular Biology 7 13%
Agricultural and Biological Sciences 7 13%
Immunology and Microbiology 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Other 9 17%
Unknown 6 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2017.
All research outputs
#7,059,669
of 9,264,233 outputs
Outputs from Autoimmunity Highlights
#15
of 27 outputs
Outputs of similar age
#186,192
of 264,046 outputs
Outputs of similar age from Autoimmunity Highlights
#2
of 2 outputs
Altmetric has tracked 9,264,233 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27 research outputs from this source. They receive a mean Attention Score of 2.5. This one scored the same or higher as 12 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,046 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.