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Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)

Overview of attention for article published in Vaccine, December 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

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12 Dimensions

Readers on

mendeley
27 Mendeley
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Title
Further development of raccoon poxvirus-vectored vaccines against plague (Yersinia pestis)
Published in
Vaccine, December 2009
DOI 10.1016/j.vaccine.2009.10.043
Pubmed ID
Authors

Tonie E. Rocke, Keith P. Iams, Sandra Dawe, Susan R. Smith, Judy L. Williamson, Dennis M. Heisey, Jorge E. Osorio

Abstract

In previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (RCN) virus-vectored vaccine that expressed the F1 capsular antigen of Yersinia pestis. In order to improve vaccine efficacy, we have now constructed additional RCN-plague vaccines containing two different forms of the lcrV (V) gene, including full-length (Vfull) and a truncated form (V307). Mouse challenge studies with Y. pestis strain CO92 showed that vaccination with a combination of RCN-F1 and the truncated V construct (RCN-V307) provided the greatest improvement (P=0.01) in protection against plague over vaccination with RCN-F1 alone. This effect was mediated primarily by anti-F1 and anti-V antibodies and both contributed independently to increased survival of vaccinated mice.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 37%
Researcher 7 26%
Other 4 15%
Student > Doctoral Student 2 7%
Student > Master 1 4%
Other 2 7%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 37%
Veterinary Science and Veterinary Medicine 4 15%
Medicine and Dentistry 3 11%
Environmental Science 2 7%
Psychology 2 7%
Other 4 15%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2016.
All research outputs
#3,027,057
of 15,555,405 outputs
Outputs from Vaccine
#2,871
of 12,632 outputs
Outputs of similar age
#64,231
of 267,203 outputs
Outputs of similar age from Vaccine
#45
of 157 outputs
Altmetric has tracked 15,555,405 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,632 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,203 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.