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Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers

Overview of attention for article published in Nature Communications, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
16 news outlets
blogs
1 blog
twitter
41 tweeters

Readers on

mendeley
57 Mendeley
citeulike
1 CiteULike
Title
Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
Published in
Nature Communications, August 2016
DOI 10.1038/ncomms12498
Pubmed ID
Authors

Christopher A. Miller, Yevgeniy Gindin, Charles Lu, Obi L Griffith, Malachi Griffith, Dong Shen, Jeremy Hoog, Tiandao Li, David E. Larson, Mark Watson, Sherri R Davies, Kelly Hunt, Vera J. Suman, Jacqueline Snider, Thomas Walsh, Graham A. Colditz, Katherine DeSchryver, Richard K. Wilson, Elaine R. Mardis, Matthew J. Ellis, Miller, Christopher A, Gindin, Yevgeniy, Lu, Charles, Griffith, Obi L, Griffith, Malachi, Shen, Dong, Hoog, Jeremy, Li, Tiandao, Larson, David E, Watson, Mark, Davies, Sherri R, Hunt, Kelly, Suman, Vera J, Snider, Jacqueline, Walsh, Thomas, Colditz, Graham A, DeSchryver, Katherine, Wilson, Richard K, Mardis, Elaine R, Ellis, Matthew J

Abstract

Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and after 4 months of neoadjuvant aromatase inhibitor (NAI) treatment. Comparing whole-genome sequencing of tumour/normal pairs from the two time points, with coincident tumour RNA sequencing, reveals widespread spatial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI. Two cases have genomic evidence of two independent tumours, most obviously an ER- 'collision tumour', which was only detected after NAI treatment of baseline ER+ disease. Many mutations are newly detected or enriched post treatment, including two ligand-binding domain mutations in ESR1. The observed clonal complexity of the ER+ breast cancer genome suggests that precision medicine approaches based on genomic analysis of a single specimen are likely insufficient to capture all clinically significant information.

Twitter Demographics

The data shown below were collected from the profiles of 41 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Germany 1 2%
France 1 2%
Australia 1 2%
Sweden 1 2%
Netherlands 1 2%
Unknown 51 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 37%
Student > Ph. D. Student 15 26%
Professor > Associate Professor 6 11%
Other 4 7%
Student > Master 4 7%
Other 7 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 39%
Medicine and Dentistry 14 25%
Biochemistry, Genetics and Molecular Biology 12 21%
Unspecified 5 9%
Mathematics 2 4%
Other 2 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 144. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2016.
All research outputs
#60,798
of 8,776,062 outputs
Outputs from Nature Communications
#960
of 14,574 outputs
Outputs of similar age
#4,033
of 261,495 outputs
Outputs of similar age from Nature Communications
#72
of 744 outputs
Altmetric has tracked 8,776,062 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,574 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,495 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 744 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.