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Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres

Overview of attention for article published in Angewandte Chemie. International Edition, November 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
103 Dimensions

Readers on

mendeley
43 Mendeley
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Title
Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres
Published in
Angewandte Chemie. International Edition, November 2012
DOI 10.1002/anie.201206416
Pubmed ID
Authors

Amirali Popat, Benjamin P. Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, Shi Zhang Qiao

Abstract

I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
China 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Unspecified 6 14%
Professor 5 12%
Researcher 5 12%
Student > Master 4 9%
Other 12 28%
Readers by discipline Count As %
Chemistry 27 63%
Unspecified 7 16%
Materials Science 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Engineering 2 5%
Other 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2012.
All research outputs
#1,117,595
of 12,179,883 outputs
Outputs from Angewandte Chemie. International Edition
#4,001
of 29,293 outputs
Outputs of similar age
#11,585
of 125,849 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#19
of 107 outputs
Altmetric has tracked 12,179,883 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 29,293 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 125,849 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.