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Specific association of human telomerase activity with immortal cells and cancer

Overview of attention for article published in Science, December 1994
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

blogs
2 blogs
twitter
1 tweeter
patent
162 patents
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
5336 Dimensions

Readers on

mendeley
1100 Mendeley
citeulike
3 CiteULike
connotea
3 Connotea
Title
Specific association of human telomerase activity with immortal cells and cancer
Published in
Science, December 1994
DOI 10.1126/science.7605428
Pubmed ID
Authors

N. Kim, M. Piatyszek, K. Prowse, C. Harley, M. West, P. Ho, G. Coviello, W. Wright, S. Weinrich, J. Shay

Abstract

Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 16 1%
United Kingdom 8 <1%
Japan 5 <1%
Turkey 4 <1%
Canada 4 <1%
Spain 3 <1%
Belgium 3 <1%
Netherlands 2 <1%
Switzerland 2 <1%
Other 13 1%
Unknown 1040 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 275 25%
Student > Bachelor 205 19%
Student > Master 176 16%
Researcher 146 13%
Student > Doctoral Student 64 6%
Other 141 13%
Unknown 93 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 346 31%
Biochemistry, Genetics and Molecular Biology 300 27%
Medicine and Dentistry 118 11%
Chemistry 87 8%
Pharmacology, Toxicology and Pharmaceutical Science 30 3%
Other 96 9%
Unknown 123 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2020.
All research outputs
#767,209
of 15,175,914 outputs
Outputs from Science
#16,810
of 65,912 outputs
Outputs of similar age
#735,575
of 14,272,662 outputs
Outputs of similar age from Science
#16,802
of 65,811 outputs
Altmetric has tracked 15,175,914 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 65,912 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 49.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 14,272,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 65,811 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.