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Recurrent asthma exacerbations: co-existing asthma and common variable immunodeficiency

Overview of attention for article published in Journal of Asthma, May 2021
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Title
Recurrent asthma exacerbations: co-existing asthma and common variable immunodeficiency
Published in
Journal of Asthma, May 2021
DOI 10.1080/02770903.2021.1922913
Pubmed ID
Authors

H. Ibrahim, J. Walsh, D. Casey, J. Murphy, B. J. Plant, P. O’Leary, D. M. Murphy

Abstract

Common variable immunodeficiency is characterised by impaired B-cell differentiation and defective immunoglobulin production manifesting as recurrent respiratory tract infections. While the condition can masquerade as asthma, late diagnosis of CVID in known asthmatic is rarely reported. We present the case of a 43-year-old lady with recurrent episodes of wheeze, cough, sinusitis and multiple lower respiratory tract infections. transiently responsive to antibiotics and steroids. These episodes had been occurring for many years and she had a longstanding clinical diagnosis of asthma. As part of her work up for recurrent respiratory tract infections a CT thorax was performed and demonstrated bronchiectasis. Further tests including Immunoglobulin levels revealed critically low IgG, IgM, and IgA levels. Immunoglobulin replacement therapy was commenced with a reduction in exacerbation frequency and severity, and objective improvement of asthma control. Subsequent lung function tests demonstrated reversible airflow limitation (obstructive lung function with 13% reversibility in FEV1 post-bronchodilator) consistent with asthma. Our case illustrates the importance of searching for alternate and co-existent diagnoses in patients diagnosed with asthma who are unresponsive to conventional therapy. We believe that serum immunoglobulin measurement should form a component of such a workup.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 29%
Unspecified 1 14%
Student > Bachelor 1 14%
Researcher 1 14%
Other 1 14%
Other 0 0%
Unknown 1 14%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%
Unspecified 1 14%
Agricultural and Biological Sciences 1 14%
Nursing and Health Professions 1 14%
Other 0 0%
Unknown 1 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2021.
All research outputs
#20,707,815
of 23,308,124 outputs
Outputs from Journal of Asthma
#1,804
of 2,057 outputs
Outputs of similar age
#365,759
of 440,140 outputs
Outputs of similar age from Journal of Asthma
#27
of 34 outputs
Altmetric has tracked 23,308,124 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,057 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,140 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.