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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance
|
|---|---|
| Published in |
BMC Medicine, August 2016
|
| DOI | 10.1186/s12916-016-0659-6 |
| Pubmed ID | |
| Authors |
Giovanni Satta, Adam A. Witney, Robert J. Shorten, Magdalena Karlikowska, Marc Lipman, Timothy D. McHugh |
| Abstract |
The largest outbreak of isoniazid-resistant (INH-R) Mycobacterium tuberculosis in Western Europe is centred in North London, with over 400 cases diagnosed since 1995. In the current study, we evaluated the genetic variation in a subset of clinical samples from the outbreak with the hypothesis that these isolates have unique biological characteristics that have served to prolong the outbreak. Fitness assays, mutation rate estimation, and whole-genome sequencing were performed to test for selective advantage and compensatory mutations. This detailed analysis of the genetic variation of these INH-R samples suggests that this outbreak consists of successful, closely related, circulating strains with heterogeneous resistance profiles and little or no associated fitness cost or impact on their mutation rate. Specific deletions and SNPs could be a peculiar feature of these INH-R M. tuberculosis isolates, and could potentially explain their persistence over the years. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 76 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 21% |
| Researcher | 10 | 13% |
| Student > Ph. D. Student | 8 | 10% |
| Student > Bachelor | 7 | 9% |
| Student > Postgraduate | 4 | 5% |
| Other | 12 | 15% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 19% |
| Medicine and Dentistry | 13 | 17% |
| Agricultural and Biological Sciences | 10 | 13% |
| Immunology and Microbiology | 5 | 6% |
| Computer Science | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2017.
All research outputs
#14,858,030
of 22,883,326 outputs
Outputs from BMC Medicine
#3,003
of 3,438 outputs
Outputs of similar age
#190,988
of 313,450 outputs
Outputs of similar age from BMC Medicine
#39
of 46 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,450 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.