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Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation

Overview of attention for article published in BMC Biology, August 2016
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Mentioned by

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4 tweeters

Citations

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14 Dimensions

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26 Mendeley
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Title
Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation
Published in
BMC Biology, August 2016
DOI 10.1186/s12915-016-0293-y
Pubmed ID
Authors

Mingli Li, Jillian L. Lindblad, Ernesto Perez, Andreas Bergmann, Yun Fan

Abstract

ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer. Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development. In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 4%
Austria 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 35%
Student > Master 5 19%
Researcher 3 12%
Student > Postgraduate 2 8%
Student > Doctoral Student 2 8%
Other 3 12%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 46%
Biochemistry, Genetics and Molecular Biology 10 38%
Neuroscience 1 4%
Medicine and Dentistry 1 4%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2016.
All research outputs
#7,598,950
of 12,599,217 outputs
Outputs from BMC Biology
#937
of 1,135 outputs
Outputs of similar age
#133,594
of 262,064 outputs
Outputs of similar age from BMC Biology
#1
of 1 outputs
Altmetric has tracked 12,599,217 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,135 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,064 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them