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Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame?

Overview of attention for article published in Breast Cancer Research, November 2012
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Title
Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame?
Published in
Breast Cancer Research, November 2012
DOI 10.1186/bcr3338
Pubmed ID
Authors

Max S Wicha

Abstract

ABSTRACT: Breast cancer metastasis accounts for the majority of deaths from this disease. In the previous issue of Breast Cancer Research, Patsialou and colleagues used a novel in vivo invasion assay to capture migrating breast cancer cells and demonstrate that the gene expression signature of these cells predicts breast cancer metastasis in a large cohort of patients. Furthermore, specific genes identified play a functional role in the invasion of MDA-MB-231 breast cancer cells and in patient-derived breast tumors. These genes regulate pathways known to be induced in invasion and metastases and play an important role in the regulation of cancer stem cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 8%
United States 1 4%
Unknown 23 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 38%
Student > Bachelor 3 12%
Professor 3 12%
Student > Ph. D. Student 2 8%
Student > Doctoral Student 1 4%
Other 4 15%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 54%
Biochemistry, Genetics and Molecular Biology 5 19%
Medicine and Dentistry 2 8%
Business, Management and Accounting 1 4%
Engineering 1 4%
Other 0 0%
Unknown 3 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2012.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Breast Cancer Research
#1,706
of 2,053 outputs
Outputs of similar age
#149,219
of 192,221 outputs
Outputs of similar age from Breast Cancer Research
#25
of 34 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,221 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.