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In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

Overview of attention for article published in Journal of Inorganic Biochemistry, October 2016
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Title
In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
Published in
Journal of Inorganic Biochemistry, October 2016
DOI 10.1016/j.jinorgbio.2016.08.002
Pubmed ID
Authors

Bao-Jing Chen, Nazzatush Shimar Jamaludin, Chai-Hoon Khoo, Tian-Hong See, Jiun-Horng Sim, Yoke-Kqueen Cheah, Siti Nadiah Abdul Halim, Hoi-Ling Seng, Edward R.T. Tiekink

Abstract

Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et (3) and Rꞌ2=(CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 35%
Student > Master 3 12%
Professor 3 12%
Student > Ph. D. Student 2 8%
Professor > Associate Professor 2 8%
Other 3 12%
Unknown 4 15%
Readers by discipline Count As %
Chemistry 7 27%
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 4 15%
Engineering 2 8%
Immunology and Microbiology 1 4%
Other 2 8%
Unknown 5 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#12,487,354
of 14,123,042 outputs
Outputs from Journal of Inorganic Biochemistry
#963
of 1,166 outputs
Outputs of similar age
#221,778
of 263,421 outputs
Outputs of similar age from Journal of Inorganic Biochemistry
#21
of 33 outputs
Altmetric has tracked 14,123,042 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,166 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,421 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.