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X Demographics
Mendeley readers
Attention Score in Context
| Title |
In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
|
|---|---|
| Published in |
Journal of Inorganic Biochemistry, August 2016
|
| DOI | 10.1016/j.jinorgbio.2016.08.002 |
| Pubmed ID | |
| Authors |
Bao-Jing Chen, Nazzatush Shimar Jamaludin, Chai-Hoon Khoo, Tian-Hong See, Jiun-Horng Sim, Yoke-Kqueen Cheah, Siti Nadiah Abdul Halim, Hoi-Ling Seng, Edward R.T. Tiekink |
| Abstract |
Four compounds, R3PAu[S2CN(CH2CH2OH)2], R=Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ=Rꞌ=Et (3) and Rꞌ2=(CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 30% |
| Student > Master | 4 | 13% |
| Professor | 3 | 10% |
| Student > Postgraduate | 2 | 7% |
| Student > Ph. D. Student | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 23% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Agricultural and Biological Sciences | 4 | 13% |
| Unspecified | 1 | 3% |
| Chemical Engineering | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 9 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from Journal of Inorganic Biochemistry
#1,634
of 1,921 outputs
Outputs of similar age
#339,890
of 381,824 outputs
Outputs of similar age from Journal of Inorganic Biochemistry
#12
of 20 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,921 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 381,824 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.