Title |
The origin and role of innate lymphoid cells in the lung
|
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Published in |
Military Medical Research, August 2016
|
DOI | 10.1186/s40779-016-0093-2 |
Pubmed ID | |
Authors |
Deng-Ming Lai, Qiang Shu, Jie Fan |
Abstract |
Innate lymphoid cells (ILCs), a newly identified member of the lymphoid population, play a critical role in the transition from innate to adaptive immunity in host defense. ILCs are important in mucosal barrier immunity, tissue homeostasis, and immune regulation throughout the body. Significant alterations in ILC responses in lung diseases have been observed and reported. Emerging evidence has shown that ILCs are importantly involved in the pathogenesis and development of a variety of lung diseases, i.e., helminth infections, allergic airway inflammation, and airway hyper-responsiveness. However, as a tissue-resident cell population, the role of ILCs in the lung remains poorly characterized. In this review, we discuss the role of ILCs in lung diseases, the mechanisms underlying the ILC-mediated regulation of immunity, and the therapeutic potential of modulating ILC responses. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Russia | 1 | 1% |
Argentina | 1 | 1% |
Unknown | 90 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 16 | 17% |
Student > Ph. D. Student | 15 | 16% |
Student > Bachelor | 12 | 13% |
Researcher | 10 | 11% |
Student > Postgraduate | 7 | 8% |
Other | 15 | 16% |
Unknown | 17 | 18% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 28 | 30% |
Medicine and Dentistry | 20 | 22% |
Agricultural and Biological Sciences | 10 | 11% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 5 | 5% |
Unknown | 19 | 21% |