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Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

Overview of attention for article published in Angewandte Chemie. International Edition, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#19 of 40,093)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
29 news outlets
blogs
6 blogs
twitter
3 tweeters
patent
4 patents
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
94 Dimensions

Readers on

mendeley
162 Mendeley
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Title
Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors
Published in
Angewandte Chemie. International Edition, August 2016
DOI 10.1002/anie.201606123
Pubmed ID
Authors

Piyush K. Jain, Vyas Ramanan, Arnout G. Schepers, Nisha S. Dalvie, Apekshya Panda, Heather E. Fleming, Sangeeta N. Bhatia

Abstract

The ability to remotely trigger CRISPR/Cas9 activity would enable new strategies to study cellular events with greater precision and complexity. In this work, we have developed a method to photocage the activity of the guide RNA called "CRISPR-plus" (CRISPR-precise light-mediated unveiling of sgRNAs). The photoactivation capability of our CRISPR-plus method is compatible with the simultaneous targeting of multiple DNA sequences and supports numerous modifications that can enable guide RNA labeling for use in imaging and mechanistic investigations.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 161 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 24%
Researcher 28 17%
Student > Master 26 16%
Student > Doctoral Student 14 9%
Student > Bachelor 14 9%
Other 23 14%
Unknown 18 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 48 30%
Chemistry 30 19%
Agricultural and Biological Sciences 30 19%
Engineering 10 6%
Medicine and Dentistry 9 6%
Other 9 6%
Unknown 26 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 259. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2021.
All research outputs
#85,041
of 19,206,351 outputs
Outputs from Angewandte Chemie. International Edition
#19
of 40,093 outputs
Outputs of similar age
#2,308
of 274,739 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#2
of 881 outputs
Altmetric has tracked 19,206,351 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 40,093 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,739 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 881 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.