Title |
Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases
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Published in |
BMC Cancer, July 2016
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DOI | 10.1186/s12885-016-2471-2 |
Pubmed ID | |
Authors |
Amanda Tufman, Rudolf Maria Huber, Stefanie Völk, Frederic Aigner, Martin Edelmann, Fernando Gamarra, Rosemarie Kiefl, Kathrin Kahnert, Fei Tian, Anne-Laure Boulesteix, Stefan Endres, Sebastian Kobold |
Abstract |
Interleukin-22 (IL-22) is involved in lung diseases such as pneumonia, asthma and lung cancer. Lavage mirrors the local environment, and may provide insights into the presence and role of IL-22 in patients. Bronchoscopic lavage (BL) samples (n = 195, including bronchoalveolar lavage and bronchial washings) were analysed for IL-22 using an enzyme-linked immunosorbent assay. Clinical characteristics and parameters from lavage and serum were correlated with lavage IL-22 concentrations. IL-22 was higher in lavage from patients with lung disease than in controls (38.0 vs 15.3 pg/ml, p < 0.001). Patients with pneumonia and lung cancer had the highest concentrations (48.9 and 33.0 pg/ml, p = 0.009 and p < 0.001, respectively). IL-22 concentration did not correlate with systemic inflammation. IL-22 concentrations did not relate to any of the analysed cell types in BL indicating a potential mixed contribution of different cell populations to IL-22 production. Lavage IL-22 concentrations are high in patients with lung cancer but do not correlate with systemic inflammation, thus suggesting that lavage IL-22 may be related to the underlying malignancy. Our results suggest that lavage may represent a distinct compartment where the role of IL-22 in thoracic malignancies can be studied. |
X Demographics
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 19% |
Student > Doctoral Student | 3 | 14% |
Student > Master | 3 | 14% |
Professor > Associate Professor | 2 | 10% |
Researcher | 2 | 10% |
Other | 4 | 19% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 48% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Agricultural and Biological Sciences | 2 | 10% |
Nursing and Health Professions | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 14% |