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Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells

Overview of attention for article published in Stem Cell Research & Therapy, August 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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4 tweeters

Citations

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48 Dimensions

Readers on

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62 Mendeley
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Title
Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells
Published in
Stem Cell Research & Therapy, August 2016
DOI 10.1186/s13287-016-0366-4
Pubmed ID
Authors

Vindya Lankika Udalamaththa, Chanika Dilumi Jayasinghe, Preethi Vidya Udagama

Abstract

Stem cell therapy has revolutionized modern clinical therapy with the potential of stem cells to differentiate into many different cell types which may help to replace different cell lines of an organism. Innumerous trials are carried out to merge new scientific knowledge and techniques with traditional herbal extracts that may result in less toxic, affordable, and highly available natural alternative therapeutics. Currently, mesenchyamal stromal cell (MSC) lines are treated with individual and mixtures of crude herbal extracts, as well as with purified compounds from herbal extracts, to investigate the mechanisms and effects of these on stem cell growth and differentiation. Human MSCs (hMSCs) possess multilineage, i.e., osteogenic, neurogenic, adipogenic, chondrogenic, and myogenic, differentiation abilities. The proliferative and differentiation properties of hMSCs treated with herbal extracts have shown promise in diseases such as osteoporosis, neurodegenerative disorders, and other tissue degenerative disorders. Well characterized herbal extracts that result in increased rates of tissue regeneration may be used in both stem cell therapy and tissue engineering for replacement therapy, where the use of scaffolds and vesicles with enhanced attaching and proliferative properties could be highly advantageous in the latter. Although the clinical application of herbal extracts is still in progress due to the variability and complexity of bioactive constituents, standardized herbal preparations will strengthen their application in the clinical context. We have critically reviewed the proliferative and differentiation effects of individual herbal extracts on hMSCs mainly derived from bone marrow and elaborated on the plausible underlying mechanisms of action. To be fruitfully used in reparative and regenerative therapy, future directions in this area of study should (i) make use of hMSCs derived from different non-traditional sources, including medical waste material (umbilical cord, Wharton's jelly, and placenta), (ii) take account of the vast numbers of herbal extracts used in traditional medicine globally, and (iii) investigate the mechanisms and pathways of their effects on hMSCs.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 21%
Student > Bachelor 10 16%
Student > Ph. D. Student 9 15%
Researcher 8 13%
Student > Doctoral Student 5 8%
Other 6 10%
Unknown 11 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 18%
Agricultural and Biological Sciences 10 16%
Medicine and Dentistry 7 11%
Immunology and Microbiology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 10 16%
Unknown 18 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2017.
All research outputs
#6,869,745
of 12,219,921 outputs
Outputs from Stem Cell Research & Therapy
#461
of 1,019 outputs
Outputs of similar age
#118,520
of 261,965 outputs
Outputs of similar age from Stem Cell Research & Therapy
#16
of 41 outputs
Altmetric has tracked 12,219,921 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,019 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,965 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.