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Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino…

Overview of attention for article published in Cardiovascular Diabetology, August 2016
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45 Mendeley
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Title
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids
Published in
Cardiovascular Diabetology, August 2016
DOI 10.1186/s12933-016-0435-0
Pubmed ID
Authors

Katherine E. Beaney, Jackie A. Cooper, Stela McLachlan, S. Goya Wannamethee, Barbara J. Jefferis, Peter Whincup, Yoav Ben-Shlomo, Jacqueline F. Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Mika Kivimaki, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Fotios Drenos, Steve E. Humphries, on behalf of the UCLEB consortium

Abstract

An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D, whether rs10911021 was associated with levels of amino acids involved in the γ-glutamyl cycle or any conventional risk factors (CRFs) for CHD in the T2D participants. Four UCLEB studies (n = 6531) had rs10911021 imputation, CHD in T2D, CRF and metabolomics data determined using a nuclear magnetic resonance based platform. The expected direction of effect between rs10911021 and CHD in T2D was observed (1377 no CHD/160 CHD; minor allele OR 0.80, 95 % CI 0.60-1.06) although this was not statistically significant (p = 0.13). No association between rs10911021 and CHD was seen in non-T2D participants (11218 no CHD/1274 CHD; minor allele OR 1.00 95 % CIs 0.92-1.10). In T2D participants, while no associations were observed between rs10911021 and the nine amino acids measured, rs10911021 was associated with HDL-cholesterol (p = 0.0005) but the minor "protective" allele was associated with lower levels (-0.034 mmol/l per allele). Focusing more closely on the HDL-cholesterol subclasses measured, we observed that rs10911021 was associated with six large HDL particle measures in T2D (all p < 0.001). No significant associations were seen in non-T2D subjects. Our findings are consistent with a true association between rs10911021 and CHD in T2D. The protective minor allele was associated with lower HDL-cholesterol and reductions in HDL particle traits. Our results indicate a complex relationship between rs10911021 and CHD in T2D.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 11%
Student > Bachelor 4 9%
Student > Master 4 9%
Student > Doctoral Student 3 7%
Other 3 7%
Other 8 18%
Unknown 18 40%
Readers by discipline Count As %
Medicine and Dentistry 10 22%
Sports and Recreations 3 7%
Biochemistry, Genetics and Molecular Biology 2 4%
Business, Management and Accounting 1 2%
Nursing and Health Professions 1 2%
Other 5 11%
Unknown 23 51%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2017.
All research outputs
#14,858,822
of 22,884,315 outputs
Outputs from Cardiovascular Diabetology
#782
of 1,386 outputs
Outputs of similar age
#209,359
of 343,744 outputs
Outputs of similar age from Cardiovascular Diabetology
#15
of 34 outputs
Altmetric has tracked 22,884,315 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,386 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,744 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.