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An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

Overview of attention for article published in Nature Immunology, March 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
twitter
10 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
188 Dimensions

Readers on

mendeley
110 Mendeley
citeulike
2 CiteULike
connotea
1 Connotea
Title
An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells
Published in
Nature Immunology, March 2010
DOI 10.1038/ni.1855
Pubmed ID
Authors

Woo-Yong Lee, Tara J Moriarty, Connie H Y Wong, Hong Zhou, Robert M Strieter, Nico van Rooijen, George Chaconas, Paul Kubes

Abstract

Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells). Immobilized Kupffer cells with highly ramified extended processes into multiple sinusoids could effectively capture blood-borne, disseminating Borrelia burgdorferi, creating a highly efficient surveillance and filtering system. After ingesting B. burgdorferi, Kupffer cells induced chemokine receptor CXCR3-dependent clustering of iNKT cells. Kupffer cells and iNKT cells formed stable contacts via the antigen-presenting molecule CD1d, which led to iNKT cell activation. An absence of iNKT cells caused B. burgdorferi to leave the blood and enter the joints more effectively. B. burgdorferi that escaped Kupffer cells entered the liver parenchyma and survived despite Ito cell responses. Kupffer cell-iNKT cell interactions induced a key intravascular immune response that diminished the dissemination of B. burgdorferi.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 8%
Netherlands 2 2%
Germany 2 2%
Italy 1 <1%
Mexico 1 <1%
Japan 1 <1%
United Kingdom 1 <1%
France 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 91 83%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 28%
Researcher 29 26%
Student > Master 17 15%
Student > Bachelor 6 5%
Student > Postgraduate 6 5%
Other 21 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 47%
Medicine and Dentistry 23 21%
Immunology and Microbiology 17 15%
Biochemistry, Genetics and Molecular Biology 9 8%
Unspecified 5 5%
Other 4 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2018.
All research outputs
#1,055,870
of 12,544,848 outputs
Outputs from Nature Immunology
#544
of 2,789 outputs
Outputs of similar age
#1,025,866
of 12,003,255 outputs
Outputs of similar age from Nature Immunology
#543
of 2,782 outputs
Altmetric has tracked 12,544,848 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,789 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 12,003,255 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 2,782 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.