Title |
IMP3 can predict aggressive behaviour of lung adenocarcinoma
|
---|---|
Published in |
Diagnostic Pathology, November 2012
|
DOI | 10.1186/1746-1596-7-165 |
Pubmed ID | |
Authors |
Renata Beljan Perak, Merica Glavina Durdov, Vesna Capkun, Veljka Ivcevic, Antonia Pavlovic, Violeta Soljic, Mari Peric |
Abstract |
Lung cancer most often presents as an inoperable tumour and the diagnosis is usually performed on a small biopsy/cytology specimen. In the group of non small cell lung cancer - not otherwise specified, adenocarcinoma phenotype can be determined immunohistochemically using TTF-1 and Napsin A. Expression of oncofetal protein IMP3 in human cancer is associated with poor differentiation and aggressive behaviour. In the present study expression of IMP3 was correlated with expression of TTF-1 and Napsin A, histological subtype and clinical stage of lung adenocarcinoma. We were interested whether distant metastases are associated with IMP3 overexpression, regardless of the histologic subtype of adenocarcinoma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 27% |
Student > Bachelor | 3 | 20% |
Student > Postgraduate | 2 | 13% |
Professor | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 40% |
Psychology | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Computer Science | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 27% |