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Mendeley readers
Attention Score in Context
| Title |
LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
|
|---|---|
| Published in |
Journal of Neuroinflammation, November 2012
|
| DOI | 10.1186/1742-2094-9-261 |
| Pubmed ID | |
| Authors |
Daniel F Marker, Jenna M Puccini, Taryn E Mockus, Justin Barbieri, Shao-Ming Lu, Harris A Gelbard |
| Abstract |
Human Immunodeficiency Virus-1 (HIV-1) associated neurocognitive disorders (HANDs) are accompanied by significant morbidity, which persists despite the use of combined antiretroviral therapy (cART). While activated microglia play a role in pathogenesis, changes in their immune effector functions, including phagocytosis and proinflammatory signaling pathways, are not well understood. We have identified leucine-rich repeat kinase 2 (LRRK2) as a novel regulator of microglial phagocytosis and activation in an in vitro model of HANDs, and hypothesize that LRRK2 kinase inhibition will attenuate microglial activation during HANDs. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 26% |
| Student > Master | 13 | 14% |
| Researcher | 11 | 12% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 8 | 9% |
| Unknown | 21 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 20% |
| Neuroscience | 16 | 18% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Medicine and Dentistry | 11 | 12% |
| Immunology and Microbiology | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 24 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2012.
All research outputs
#4,564,719
of 22,687,320 outputs
Outputs from Journal of Neuroinflammation
#942
of 2,611 outputs
Outputs of similar age
#47,728
of 277,026 outputs
Outputs of similar age from Journal of Neuroinflammation
#4
of 22 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,611 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,026 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.