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Intrabronchial activated protein C enhances lipopolysaccharide-induced pulmonary responses

Overview of attention for article published in European Respiratory Journal, October 2012
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Title
Intrabronchial activated protein C enhances lipopolysaccharide-induced pulmonary responses
Published in
European Respiratory Journal, October 2012
DOI 10.1183/09031936.00057112
Pubmed ID
Authors

M Kager L, Daan de Boer J, Bresser P, van der Zee JS, Zeerleder S, Meijers JC, van 't Veer C, van der Poll T, Liesbeth M. Kager, J. Daan de Boer, Paul Bresser, Jaring S. van der Zee, Sacha Zeerleder, Joost C.M. Meijers, Cornelis van 't Veer, Tom van der Poll

Abstract

Intravenous administration of activated protein C (APC) inhibits coagulation and inflammation in the lungs of humans and animals. Investigations in rodents demonstrated that direct intrapulmonary delivery of APC also exerts anticoagulant and anti-inflammatory effects. The effect of intrabronchial administration of recombinant human (rh)APC on lipopolysaccharide (LPS)-induced haemostatic and inflammatory alterations in the bronchoalveolar space of humans was studied. Eight subjects received rhAPC via intrabronchial instillation by bronchoscope, while in a contralateral subsegment subjects received saline; all subjects were challenged bilaterally with LPS in the same lung subsegments. Four additional subjects received rhAPC (75 μg), with saline as a control in the contralateral subsegment, while they were bilaterally "challenged" with saline. After 6 h a bronchoalveolar lavage was performed and coagulation and inflammatory parameters were measured. rhAPC enhanced LPS-induced coagulation activation in the bronchoalveolar space, when compared with the control side. In addition, rhAPC amplified LPS-induced pro-inflammatory responses, as indicated by higher concentrations of cytokines and chemokines. rhAPC alone did not have procoagulant or pro-inflammatory effects. Locally administered rhAPC has unexpected procoagulant and pro-inflammatory effects in LPS-challenged lung subsegments. These data argue against a role for intrapulmonary delivery of rhAPC as a treatment strategy for lung inflammatory disorders in humans.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Professor 2 14%
Student > Doctoral Student 2 14%
Researcher 2 14%
Professor > Associate Professor 2 14%
Other 3 21%
Readers by discipline Count As %
Medicine and Dentistry 6 43%
Agricultural and Biological Sciences 3 21%
Unspecified 2 14%
Biochemistry, Genetics and Molecular Biology 2 14%
Immunology and Microbiology 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2012.
All research outputs
#2,017,242
of 3,628,496 outputs
Outputs from European Respiratory Journal
#1,144
of 1,802 outputs
Outputs of similar age
#147,305
of 275,747 outputs
Outputs of similar age from European Respiratory Journal
#146
of 198 outputs
Altmetric has tracked 3,628,496 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,802 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,747 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 198 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.