Title |
Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis
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Published in |
BMC Veterinary Research, November 2012
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DOI | 10.1186/1746-6148-8-230 |
Pubmed ID | |
Authors |
Santiago Cerrato, Pilar Brazis, Maria Federica della Valle, Alda Miolo, Anna Puigdemont |
Abstract |
Adelmidrol is a semisynthetic derivative of azelaic acid and analogue of the anti-inflammatory compound palmitoylethanolamide (PEA). Based upon its physicochemical properties, adelmidrol is suitable for topical application. The main objective of the present study was to evaluate the efficacy of a topical adelmidrol emulsion on early and late inflammatory responses in hypersensitive dogs. Repeated intradermal injections of Ascaris suum extract were performed in both lateral thoracic areas of six conscious hypersensitive Beagle dogs, topically treated during 8 consecutive days. Adelmidrol (2%) was applied to one side and vehicle to the other. 24 hours after the last antigen challenge, two biopsies (adelmidrol- and vehicle-treated side) were obtained for each dog at the antigen injection site. |
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Geographical breakdown
Country | Count | As % |
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Italy | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 29% |
Other | 4 | 14% |
Student > Bachelor | 4 | 14% |
Student > Master | 3 | 11% |
Lecturer | 1 | 4% |
Other | 4 | 14% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 7 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 11% |
Medicine and Dentistry | 3 | 11% |
Immunology and Microbiology | 3 | 11% |
Agricultural and Biological Sciences | 2 | 7% |
Other | 6 | 21% |
Unknown | 4 | 14% |