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Improving basic and translational science by accounting for litter-to-litter variation in animal models

Overview of attention for article published in BMC Neuroscience, March 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
twitter
10 X users
facebook
4 Facebook pages
wikipedia
1 Wikipedia page
reddit
1 Redditor

Citations

dimensions_citation
201 Dimensions

Readers on

mendeley
226 Mendeley
citeulike
2 CiteULike
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Title
Improving basic and translational science by accounting for litter-to-litter variation in animal models
Published in
BMC Neuroscience, March 2013
DOI 10.1186/1471-2202-14-37
Pubmed ID
Authors

Stanley E Lazic, Laurent Essioux

Abstract

Animals from the same litter are often more alike compared with animals from different litters. This litter-to-litter variation, or "litter effects", can influence the results in addition to the experimental factors of interest. Furthermore, sometimes an experimental treatment can only be applied to whole litters rather than to individual offspring. An example is the valproic acid (VPA) model of autism, where VPA is administered to pregnant females thereby inducing the disease phenotype in the offspring. With this type of experiment the sample size is the number of litters and not the total number of offspring. If such experiments are not appropriately designed and analysed, the results can be severely biased as well as extremely underpowered.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 226 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
France 1 <1%
Hong Kong 1 <1%
Brazil 1 <1%
Canada 1 <1%
Spain 1 <1%
Unknown 220 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 26%
Researcher 32 14%
Student > Master 32 14%
Student > Bachelor 17 8%
Student > Doctoral Student 11 5%
Other 32 14%
Unknown 43 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 22%
Neuroscience 36 16%
Medicine and Dentistry 29 13%
Psychology 16 7%
Biochemistry, Genetics and Molecular Biology 8 4%
Other 26 12%
Unknown 61 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2022.
All research outputs
#2,146,750
of 24,614,554 outputs
Outputs from BMC Neuroscience
#59
of 1,272 outputs
Outputs of similar age
#17,268
of 201,396 outputs
Outputs of similar age from BMC Neuroscience
#1
of 30 outputs
Altmetric has tracked 24,614,554 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,272 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,396 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.