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Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction

Overview of attention for article published in Virology Journal, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

twitter
5 tweeters
patent
1 patent
facebook
2 Facebook pages

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
27 Mendeley
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Title
Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction
Published in
Virology Journal, January 2012
DOI 10.1186/1743-422x-9-303
Pubmed ID
Authors

Jin Zhang, Ke Wang, Yan Guo, Qi Shi, Chan Tian, Cao Chen, Chen Gao, Bao-Yun Zhang, Xiao-Ping Dong

Abstract

Although the aggregation of PrPSc is thought to be crucial for the neuropathology of prion diseases, there is evidence in cultured cells and transgenic mice that neuronal death can be triggered by the accumulation of cytosolic PrPs, leading to the hypothesis that the accumulation of PrPs in the cytosol of neurons may be a primary neurotoxic culprit. Hsp70, a molecular chaperone involved in protein folding/refolding and degradation in the cytoplasm, has a protective effect in some models of neurodegenerative diseases, e.g., Alzheimer's and Parkinson's diseases, but its role in prion diseases remains unclear.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 30%
Researcher 6 22%
Other 3 11%
Professor > Associate Professor 3 11%
Professor 2 7%
Other 4 15%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 37%
Biochemistry, Genetics and Molecular Biology 8 30%
Chemistry 2 7%
Medicine and Dentistry 2 7%
Earth and Planetary Sciences 1 4%
Other 2 7%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2012.
All research outputs
#1,588,277
of 9,633,164 outputs
Outputs from Virology Journal
#186
of 1,911 outputs
Outputs of similar age
#56,545
of 301,700 outputs
Outputs of similar age from Virology Journal
#6
of 98 outputs
Altmetric has tracked 9,633,164 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,911 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,700 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.