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Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Overview of attention for article published in Endocrine Reviews, October 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
3 news outlets
twitter
6 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page
video
1 video uploader

Citations

dimensions_citation
569 Dimensions

Readers on

mendeley
493 Mendeley
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Title
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
Published in
Endocrine Reviews, October 2012
DOI 10.1210/er.2011-1034
Pubmed ID
Authors

Evanthia Diamanti-Kandarakis, Andrea Dunaif

Abstract

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected women have marked insulin resistance, independent of obesity. This article summarizes the state of the science since we last reviewed the field in the Endocrine Reviews in 1997. There is general agreement that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity. There is a post-binding defect in receptor signaling likely due to increased receptor and insulin receptor substrate-1 serine phosphorylation that selectively affects metabolic but not mitogenic pathways in classic insulin target tissues and in the ovary. Constitutive activation of serine kinases in the MAPK-ERK pathway may contribute to resistance to insulin's metabolic actions in skeletal muscle. Insulin functions as a co-gonadotropin through its cognate receptor to modulate ovarian steroidogenesis. Genetic disruption of insulin signaling in the brain has indicated that this pathway is important for ovulation and body weight regulation. These insights have been directly translated into a novel therapy for PCOS with insulin-sensitizing drugs. Furthermore, androgens contribute to insulin resistance in PCOS. PCOS may also have developmental origins due to androgen exposure at critical periods or to intrauterine growth restriction. PCOS is a complex genetic disease, and first-degree relatives have reproductive and metabolic phenotypes. Several PCOS genetic susceptibility loci have been mapped and replicated. Some of the same susceptibility genes contribute to disease risk in Chinese and European PCOS populations, suggesting that PCOS is an ancient trait.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 493 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
Brazil 3 <1%
India 2 <1%
Australia 1 <1%
Chile 1 <1%
Syrian Arab Republic 1 <1%
Norway 1 <1%
Turkey 1 <1%
Netherlands 1 <1%
Other 0 0%
Unknown 479 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 92 19%
Student > Master 81 16%
Student > Ph. D. Student 72 15%
Unspecified 54 11%
Student > Postgraduate 54 11%
Other 140 28%
Readers by discipline Count As %
Medicine and Dentistry 206 42%
Unspecified 72 15%
Agricultural and Biological Sciences 71 14%
Biochemistry, Genetics and Molecular Biology 57 12%
Nursing and Health Professions 33 7%
Other 54 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2019.
All research outputs
#543,909
of 13,635,041 outputs
Outputs from Endocrine Reviews
#52
of 933 outputs
Outputs of similar age
#8,300
of 248,415 outputs
Outputs of similar age from Endocrine Reviews
#1
of 4 outputs
Altmetric has tracked 13,635,041 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 933 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,415 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them