Title |
The importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2
|
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Published in |
Retrovirology, December 2012
|
DOI | 10.1186/1742-4690-9-103 |
Pubmed ID | |
Authors |
Linda Zane, Kuan-Teh Jeang |
Abstract |
Human T-cell Leukemia Virus type 1 (HTLV-1) and 2 (HTLV-2) are two closely related human retroviruses. HTLV-1 is associated with an aggressive Adult T-cell Leukemia (ATL) while there is no evidence for an association of HTLV-2 with any human malignancies. The two viruses encode transactivator proteins, Tax-1 and Tax-2 respectively. In ATL, Tax-1 is thought to play a central role in the transformation of a normal T-cell into a leukemic cell; however, it has not been entirely clear how post-translational modifications of Tax-1 influence its transforming activity. Here, we discuss three recent papers that report on the ubiquitination and sumoylation of Tax-1 and Tax-2. We comment on their divergent findings implicating the importance (or lack of importance) of these modifications and other events on Tax activation of NF-κB as related to cellular transformation. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 11% |
Unknown | 8 | 89% |
Demographic breakdown
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Researcher | 5 | 56% |
Student > Bachelor | 1 | 11% |
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Student > Master | 1 | 11% |
Unknown | 1 | 11% |
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Neuroscience | 1 | 11% |
Other | 0 | 0% |
Unknown | 1 | 11% |