Title |
Bariatric surgery and T2DM improvement mechanisms: a mathematical model
|
---|---|
Published in |
Theoretical Biology and Medical Modelling, May 2012
|
DOI | 10.1186/1742-4682-9-16 |
Pubmed ID | |
Authors |
Puntip Toghaw, Alice Matone, Yongwimon Lenbury, Andrea De GAETANO |
Abstract |
Consensus exists that several bariatric surgery procedures produce a rapid improvement of glucose homeostasis in obese diabetic patients, improvement apparently uncorrelated with the degree of eventual weight loss after surgery. Several hypotheses have been suggested to account for these results: among these, the anti-incretin, the ghrelin and the lower-intestinal dumping hypotheses have been discussed in the literature. Since no clear-cut experimental results are so far available to confirm or disprove any of these hypotheses, in the present work a mathematical model of the glucose-insulin-incretin system has been built, capable of expressing these three postulated mechanisms. The model has been populated with critically evaluated parameter values from the literature, and simulations under the three scenarios have been compared. |
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