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Muscle reorganisation through local injection of stem cells in the diaphragm of mdx mice

Overview of attention for article published in Acta Veterinaria Scandinavica, December 2012
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Title
Muscle reorganisation through local injection of stem cells in the diaphragm of mdx mice
Published in
Acta Veterinaria Scandinavica, December 2012
DOI 10.1186/1751-0147-54-73
Pubmed ID
Authors

Thais Borges Lessa, Rafael Cardoso Carvalho, André Luis Rezende Franciolli, Lilian Jesus de Oliveira, RodrigoSilvadaNunes Barreto, David Feder, Fabiana Fernandes Bressan, Maria Angélica Miglino, Carlos Eduardo Ambrósio

Abstract

The diaphragm is the major respiratory muscle affected by Duchenne muscular dystrophy (DMD) and is responsible for causing 80% of deaths. The use of mechanical forces that act on the body or intermittent pressure on the airways improves the quality of life of patients but does not prevent the progression of respiratory failure. Thus, diseases that require tissue repair, such as DMD, represent a group of pathologies that have great potential for cell therapy. The application of stem cells directly into the diaphragm instead of systemic application can reduce cell migration to other affected areas and increase the chances of muscle reorganisation. The mdx mouse is a suitable animal model for this research because its diaphragmatic phenotype is similar to human DMD. Therefore, the aim of this study was to assess the potential cell implantation in the diaphragm muscle after the xenotransplantation of stem cells.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 14%
Researcher 7 14%
Professor 6 12%
Student > Master 6 12%
Other 5 10%
Other 8 16%
Unknown 10 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 16%
Medicine and Dentistry 7 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Veterinary Science and Veterinary Medicine 4 8%
Other 7 14%
Unknown 14 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2012.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Acta Veterinaria Scandinavica
#552
of 837 outputs
Outputs of similar age
#226,510
of 286,181 outputs
Outputs of similar age from Acta Veterinaria Scandinavica
#4
of 10 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 837 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,181 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.