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Identification of new cell size control genes in S. cerevisiae

Overview of attention for article published in Cell Division, December 2012
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1 tweeter

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54 Mendeley
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Title
Identification of new cell size control genes in S. cerevisiae
Published in
Cell Division, December 2012
DOI 10.1186/1747-1028-7-24
Pubmed ID
Abstract

Cell size homeostasis is a conserved attribute in many eukaryotic species involving a tight regulation between the processes of growth and proliferation. In budding yeast S. cerevisiae, growth to a "critical cell size" must be achieved before a cell can progress past START and commit to cell division. Numerous studies have shown that progression past START is actively regulated by cell size control genes, many of which have implications in cell cycle control and cancer. Two initial screens identified genes that strongly modulate cell size in yeast. Since a second generation yeast gene knockout collection has been generated, we screened an additional 779 yeast knockouts containing 435 new ORFs (~7% of the yeast genome) to supplement previous cell size screens. Upon completion, 10 new strong size mutants were identified: nine in log-phase cells and one in saturation-phase cells, and 97% of the yeast genome has now been screened for cell size mutations. The majority of the logarithmic phase size mutants have functions associated with translation further implicating the central role of growth control in the cell division process. Genetic analyses suggest ECM9 is directly associated with the START transition. Further, the small (whi) mutants mrpl49Δ and cbs1Δ are dependent on CLN3 for cell size effects. In depth analyses of new size mutants may facilitate a better understanding of the processes that govern cell size homeostasis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 2%
United States 1 2%
Unknown 52 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Researcher 14 26%
Student > Bachelor 5 9%
Student > Master 5 9%
Professor 3 6%
Other 7 13%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 52%
Biochemistry, Genetics and Molecular Biology 13 24%
Physics and Astronomy 2 4%
Medicine and Dentistry 2 4%
Engineering 2 4%
Other 0 0%
Unknown 7 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2012.
All research outputs
#3,078,883
of 4,507,211 outputs
Outputs from Cell Division
#36
of 51 outputs
Outputs of similar age
#191,695
of 281,471 outputs
Outputs of similar age from Cell Division
#3
of 5 outputs
Altmetric has tracked 4,507,211 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 51 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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