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Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

Overview of attention for article published in Diagnostic Pathology, July 2012
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Title
Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers
Published in
Diagnostic Pathology, July 2012
DOI 10.1186/1746-1596-7-87
Pubmed ID
Authors

Leda Guzmán, María Soledad Depix, Ana María Salinas, Rosa Roldán, Francisco Aguayo, Alejandra Silva, Raul Vinet

Abstract

Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In this study, we hypothesize that tobacco smokers are susceptible for methylation in the promoter region of TSGs in airway epithelial cells when compared with non-smoker subjects. The purpose of this study was to investigate the usefulness of detection of genes promoter methylation in sputum specimens, as a complementary tool to identify LC biomarkers among smokers with early COPD.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Sweden 1 2%
Unknown 53 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 29%
Researcher 10 18%
Professor > Associate Professor 6 11%
Student > Master 4 7%
Student > Bachelor 4 7%
Other 7 13%
Unknown 8 15%
Readers by discipline Count As %
Medicine and Dentistry 13 24%
Agricultural and Biological Sciences 11 20%
Biochemistry, Genetics and Molecular Biology 11 20%
Immunology and Microbiology 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 7%
Unknown 10 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2012.
All research outputs
#20,176,348
of 22,689,790 outputs
Outputs from Diagnostic Pathology
#941
of 1,118 outputs
Outputs of similar age
#146,962
of 163,883 outputs
Outputs of similar age from Diagnostic Pathology
#25
of 26 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,118 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,883 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.