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Stability of miRNA 5′terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy

Overview of attention for article published in Scientific Reports, December 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
6 tweeters

Citations

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39 Dimensions

Readers on

mendeley
97 Mendeley
Title
Stability of miRNA 5′terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy
Published in
Scientific Reports, December 2012
DOI 10.1038/srep00996
Pubmed ID
Authors

Naoki Hibio, Kimihiro Hino, Eigo Shimizu, Yoshiro Nagata, Kumiko Ui-Tei

Abstract

MicroRNAs (miRNAs) are key regulators of sequence-specific gene silencing. However, crucial factors that determine the efficacy of miRNA-mediated target gene silencing are poorly understood. Here we mathematized base-pairing stability and showed that miRNAs with an unstable 5' terminal duplex and stable seed-target duplex exhibit strong silencing activity. The results are consistent with the previous findings that an RNA strand with unstable 5' terminal in miRNA duplex easily loads onto the RNA-induced silencing complex (RISC), and miRNA recognizes target mRNAs with seed-complementary sequences to direct posttranscriptional repression. Our results suggested that both the unwinding and target recognition processes of miRNAs could be proficiently controlled by the thermodynamics of base-pairing in protein-free condition. Interestingly, such thermodynamic parameters might be evolutionarily well adapted to the body temperatures of various species.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Poland 1 1%
Mexico 1 1%
Germany 1 1%
Japan 1 1%
Philippines 1 1%
United States 1 1%
Colombia 1 1%
Unknown 88 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 32%
Student > Master 16 16%
Researcher 15 15%
Student > Bachelor 13 13%
Student > Doctoral Student 7 7%
Other 15 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 66 68%
Biochemistry, Genetics and Molecular Biology 13 13%
Chemistry 5 5%
Medicine and Dentistry 5 5%
Unspecified 3 3%
Other 5 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2015.
All research outputs
#1,142,459
of 6,230,693 outputs
Outputs from Scientific Reports
#6,049
of 21,926 outputs
Outputs of similar age
#59,655
of 267,202 outputs
Outputs of similar age from Scientific Reports
#145
of 421 outputs
Altmetric has tracked 6,230,693 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,926 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,202 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 421 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.