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A novel molecular mechanism in human genetic disease

Overview of attention for article published in RNA Biology, October 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

twitter
1 X user
patent
1 patent

Citations

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19 Dimensions

Readers on

mendeley
34 Mendeley
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Title
A novel molecular mechanism in human genetic disease
Published in
RNA Biology, October 2014
DOI 10.4161/rna.21922
Pubmed ID
Authors

Daphne S. Cabianca, Valentina Casa, Davide Gabellini

Abstract

Two thirds of the human genome is composed of repetitive sequences. Despite their prevalence, DNA repeats are largely ignored. The vast majority of our genome is transcribed to produce non protein-coding RNAs. Among these, long non protein-coding RNAs represent the most prevalent and functionally diverse class. The relevance of the non protein-coding genome to human disease has mainly been studied regarding the altered microRNA expression and function in human cancer. On the contrary, the elucidation of the involvement of long non-coding RNAs in disease is only in its infancy. We have recently found that a chromatin associated, long non protein-coding RNA regulates a Polycomb/Trithorax epigenetic switch at the basis of the repeat associated facioscapulohumeral muscular dystrophy, a common muscle disorder. Based on this, we propose that long non-coding RNAs produced by repetitive sequences contribute in shaping the epigenetic landscape in normal human physiology and in disease.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 32%
Student > Master 7 21%
Student > Ph. D. Student 4 12%
Student > Bachelor 3 9%
Student > Doctoral Student 2 6%
Other 5 15%
Unknown 2 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 38%
Agricultural and Biological Sciences 12 35%
Medicine and Dentistry 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Computer Science 1 3%
Other 3 9%
Unknown 2 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2022.
All research outputs
#7,705,789
of 24,736,359 outputs
Outputs from RNA Biology
#460
of 1,532 outputs
Outputs of similar age
#80,221
of 266,038 outputs
Outputs of similar age from RNA Biology
#117
of 337 outputs
Altmetric has tracked 24,736,359 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,532 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,038 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 337 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.