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CREST maps somatic structural variation in cancer genomes with base-pair resolution

Overview of attention for article published in Nature Methods, June 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 tweeters
patent
1 patent
q&a
1 Q&A thread

Citations

dimensions_citation
328 Dimensions

Readers on

mendeley
443 Mendeley
citeulike
11 CiteULike
Title
CREST maps somatic structural variation in cancer genomes with base-pair resolution
Published in
Nature Methods, June 2011
DOI 10.1038/nmeth.1628
Pubmed ID
Authors

Jianmin Wang, Charles G Mullighan, John Easton, Stefan Roberts, Sue L Heatley, Jing Ma, Michael C Rusch, Ken Chen, Christopher C Harris, Li Ding, Linda Holmfeldt, Debbie Payne-Turner, Xian Fan, Lei Wei, David Zhao, John C Obenauer, Clayton Naeve, Elaine R Mardis, Richard K Wilson, James R Downing, Jinghui Zhang

Abstract

We developed 'clipping reveals structure' (CREST), an algorithm that uses next-generation sequencing reads with partial alignments to a reference genome to directly map structural variations at the nucleotide level of resolution. Application of CREST to whole-genome sequencing data from five pediatric T-lineage acute lymphoblastic leukemias (T-ALLs) and a human melanoma cell line, COLO-829, identified 160 somatic structural variations. Experimental validation exceeded 80%, demonstrating that CREST had a high predictive accuracy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 443 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 31 7%
Netherlands 6 1%
United Kingdom 5 1%
Italy 4 <1%
Canada 3 <1%
China 3 <1%
Germany 2 <1%
Belgium 2 <1%
France 2 <1%
Other 15 3%
Unknown 370 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 157 35%
Student > Ph. D. Student 117 26%
Student > Master 48 11%
Other 23 5%
Professor 18 4%
Other 80 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 247 56%
Biochemistry, Genetics and Molecular Biology 85 19%
Computer Science 37 8%
Medicine and Dentistry 35 8%
Unspecified 11 2%
Other 28 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2015.
All research outputs
#1,448,900
of 10,078,932 outputs
Outputs from Nature Methods
#1,559
of 3,191 outputs
Outputs of similar age
#1,400,826
of 9,427,342 outputs
Outputs of similar age from Nature Methods
#1,538
of 3,106 outputs
Altmetric has tracked 10,078,932 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,191 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 9,427,342 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 3,106 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.