Title |
Treatment for lupus nephritis
|
---|---|
Published in |
Cochrane database of systematic reviews, December 2012
|
DOI | 10.1002/14651858.cd002922.pub3 |
Pubmed ID | |
Authors |
Lorna Henderson, Philip Masson, Jonathan C Craig, Robert S Flanc, Matthew A Roberts, Giovanni FM Strippoli, Angela C Webster |
Abstract |
Cyclophosphamide, in combination with corticosteroids has been used to induce remission in proliferative lupus nephritis, the most common kidney manifestation of the multisystem disease, systemic lupus erythematosus. Cyclophosphamide therapy has reduced mortality from over 70% in the 1950s and 1960s to less than 10% in recent years. Cyclophosphamide combined with corticosteroids preserves kidney function but is only partially effective and may cause ovarian failure, infection and bladder toxicity. Several new agents, including mycophenolate mofetil (MMF), suggest reduced toxicity with equivalent rates of remission. This is an update of a Cochrane review first published in 2004. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Australia | 1 | 20% |
Brazil | 1 | 20% |
Mexico | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Colombia | 1 | <1% |
Uruguay | 1 | <1% |
Italy | 1 | <1% |
Unknown | 166 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 31 | 18% |
Student > Master | 20 | 12% |
Student > Postgraduate | 19 | 11% |
Student > Ph. D. Student | 16 | 9% |
Student > Bachelor | 15 | 9% |
Other | 46 | 27% |
Unknown | 23 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 98 | 58% |
Nursing and Health Professions | 10 | 6% |
Psychology | 6 | 4% |
Agricultural and Biological Sciences | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 15 | 9% |
Unknown | 32 | 19% |