Title |
Over-expression of mitochondrial antiviral signaling protein inhibits coxsackievirus B3 infection by enhancing type-I interferons production
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Published in |
Virology Journal, December 2012
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DOI | 10.1186/1743-422x-9-312 |
Pubmed ID | |
Authors |
Qing-Meng Zhang, Wu-Qi Song, Yu-Jun Li, Jun Qian, Ai-Xia Zhai, Jing Wu, Ai-Mei Li, Jun-Ming He, Jin-Yun Zhao, Xin Yu, Lan-Lan Wei, Feng-Min Zhang |
Abstract |
Recent studies have revealed that Mitochondrial Antiviral Signaling (MAVS) protein plays an essential role in the inhibition of viral infection through type I interferon (IFN) pathway. It has been shown that 3C (pro) cysteine protease of coxsackievirus B3 (CVB3) cleaves MAVS to inhibit type I IFNs induction. Other workers also found that MAVS knock-out mice suffered CVB3 susceptibility and severe histopathological change. Accordingly,our experiments were designed to explore the protection of over-expressing MAVS against CVB3 infection and the possible mechanism. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 22% |
Researcher | 4 | 15% |
Student > Bachelor | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Student > Master | 2 | 7% |
Other | 4 | 15% |
Unknown | 7 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Agricultural and Biological Sciences | 4 | 15% |
Computer Science | 1 | 4% |
Unspecified | 1 | 4% |
Other | 2 | 7% |
Unknown | 8 | 30% |