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Over-expression of mitochondrial antiviral signaling protein inhibits coxsackievirus B3 infection by enhancing type-I interferons production

Overview of attention for article published in Virology Journal, December 2012
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Title
Over-expression of mitochondrial antiviral signaling protein inhibits coxsackievirus B3 infection by enhancing type-I interferons production
Published in
Virology Journal, December 2012
DOI 10.1186/1743-422x-9-312
Pubmed ID
Authors

Qing-Meng Zhang, Wu-Qi Song, Yu-Jun Li, Jun Qian, Ai-Xia Zhai, Jing Wu, Ai-Mei Li, Jun-Ming He, Jin-Yun Zhao, Xin Yu, Lan-Lan Wei, Feng-Min Zhang

Abstract

Recent studies have revealed that Mitochondrial Antiviral Signaling (MAVS) protein plays an essential role in the inhibition of viral infection through type I interferon (IFN) pathway. It has been shown that 3C (pro) cysteine protease of coxsackievirus B3 (CVB3) cleaves MAVS to inhibit type I IFNs induction. Other workers also found that MAVS knock-out mice suffered CVB3 susceptibility and severe histopathological change. Accordingly,our experiments were designed to explore the protection of over-expressing MAVS against CVB3 infection and the possible mechanism.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Researcher 4 15%
Student > Bachelor 2 7%
Student > Postgraduate 2 7%
Student > Master 2 7%
Other 4 15%
Unknown 7 26%
Readers by discipline Count As %
Immunology and Microbiology 7 26%
Biochemistry, Genetics and Molecular Biology 4 15%
Agricultural and Biological Sciences 4 15%
Computer Science 1 4%
Unspecified 1 4%
Other 2 7%
Unknown 8 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2012.
All research outputs
#15,258,711
of 22,689,790 outputs
Outputs from Virology Journal
#1,938
of 3,030 outputs
Outputs of similar age
#181,217
of 280,127 outputs
Outputs of similar age from Virology Journal
#52
of 90 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,030 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,127 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.