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Mitochondrial damage and intralysosomal degradation in cellular aging.

Overview of attention for article published in Molecular Aspects of Medicine, October 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#14 of 157)
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
1 blog

Readers on

mendeley
37 Mendeley
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Title
Mitochondrial damage and intralysosomal degradation in cellular aging.
Published in
Molecular Aspects of Medicine, October 2006
DOI 10.1016/j.mam.2006.08.006
Pubmed ID
Authors

A TERMAN, B GUSTAFSSON, U BRUNK

Abstract

Normal mitochondrial respiration is associated with a continuous production of superoxide and hydrogen peroxide, inevitably resulting in minor macromolecular damage. Damaged cellular components are not completely turned over by autophagy and other cellular repair systems, leading to a progressive age-related accumulation of biological "garbage" material, such as defective mitochondria, cytoplasmic protein aggregates and an intralysosomal undegradable material, lipofuscin. These changes primarily affect neurons, cardiac myocytes and other long-lived postmitotic cells that neither dilute this "garbage" by mitotic activity, nor are replaced by newly differentiated cells. Defective mitochondria are insufficient in ATP production and often generate increased amounts of reactive oxygen species, further enhancing oxidative stress. Lipofuscin-loaded lysosomes, in turn, poorly turn over mitochondria that gradually leads to the overload of long-lived postmitotic cells with "garbage" material, decreased adaptability and eventual cell death.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Chile 1 3%
Unknown 34 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 32%
Student > Ph. D. Student 6 16%
Student > Master 5 14%
Student > Doctoral Student 4 11%
Professor 2 5%
Other 8 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 46%
Biochemistry, Genetics and Molecular Biology 8 22%
Medicine and Dentistry 4 11%
Unspecified 3 8%
Neuroscience 3 8%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2006.
All research outputs
#537,636
of 3,929,885 outputs
Outputs from Molecular Aspects of Medicine
#14
of 157 outputs
Outputs of similar age
#450,503
of 2,965,048 outputs
Outputs of similar age from Molecular Aspects of Medicine
#14
of 141 outputs
Altmetric has tracked 3,929,885 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 157 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 2,965,048 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.