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X Demographics
Mendeley readers
Attention Score in Context
| Title |
DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer
|
|---|---|
| Published in |
Genome Biology, December 2012
|
| DOI | 10.1186/gb-2012-13-12-r124 |
| Pubmed ID | |
| Authors |
Ali Bashashati, Gholamreza Haffari, Jiarui Ding, Gavin Ha, Kenneth Lui, Jamie Rosner, David G Huntsman, Carlos Caldas, Samuel A Aparicio, Sohrab P Shah |
| Abstract |
Simultaneous interrogation of tumor genomes and transcriptomes is underway in unprecedented global efforts. Yet, despite the essential need to separate driver mutations modulating gene expression networks from transcriptionally inert passenger mutations, robust computational methods to ascertain the impact of individual mutations on transcriptional networks are underdeveloped. We introduce a novel computational framework, DriverNet, to identify likely driver mutations by virtue of their effect on mRNA expression networks. Application to four cancer datasets reveals the prevalence of rare candidate driver mutations associated with disrupted transcriptional networks and a simultaneous modulation of oncogenic and metabolic networks, induced by copy number co-modification of adjacent oncogenic and metabolic drivers. DriverNet is available on Bioconductor or at http://compbio.bccrc.ca/software/drivernet/. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| United Kingdom | 1 | 14% |
| Spain | 1 | 14% |
| Japan | 1 | 14% |
| Belgium | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 57% |
| Members of the public | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Canada | 3 | 1% |
| Germany | 2 | <1% |
| France | 2 | <1% |
| Singapore | 2 | <1% |
| United Kingdom | 2 | <1% |
| Hong Kong | 1 | <1% |
| Brazil | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 219 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 27% |
| Researcher | 46 | 19% |
| Student > Master | 23 | 10% |
| Student > Bachelor | 23 | 10% |
| Student > Postgraduate | 12 | 5% |
| Other | 37 | 15% |
| Unknown | 34 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 81 | 34% |
| Biochemistry, Genetics and Molecular Biology | 46 | 19% |
| Computer Science | 41 | 17% |
| Medicine and Dentistry | 14 | 6% |
| Engineering | 9 | 4% |
| Other | 13 | 5% |
| Unknown | 36 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2017.
All research outputs
#3,099,354
of 25,374,917 outputs
Outputs from Genome Biology
#2,299
of 4,467 outputs
Outputs of similar age
#29,868
of 288,988 outputs
Outputs of similar age from Genome Biology
#24
of 50 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,988 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.