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Both G3BP1 and G3BP2 contribute to stress granule formation

Overview of attention for article published in Genes to Cells, December 2012
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

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2 tweeters
wikipedia
1 Wikipedia page

Citations

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73 Dimensions

Readers on

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87 Mendeley
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Title
Both G3BP1 and G3BP2 contribute to stress granule formation
Published in
Genes to Cells, December 2012
DOI 10.1111/gtc.12023
Pubmed ID
Authors

Hideaki Matsuki, Masahiko Takahashi, Masaya Higuchi, Grace N Makokha, Masayasu Oie, Masahiro Fujii

Abstract

Upon exposure to various environmental stresses such as arsenite, hypoxia, and heat shock, cells inhibit their translation and apoptosis and then repair stress-induced alterations, such as DNA damage and the accumulation of misfolded proteins. These types of stresses induce the formation of cytoplasmic RNA granules called stress granules (SGs). SGs are storage sites for the many mRNAs released from disassembled polysomes under these stress conditions and are essential for the selective translation of stress-inducible genes. Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a component of SGs that initiates the assembly of SGs by forming a multimer. In this study, we examined the role of G3BP2, a close relative of G3BP1, in SG formation. Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number. G3BP2 formed a homo-multimer and a hetero-multimer with G3BP1. Moreover, like G3BP1, the overexpression of G3BP2 induced SGs even without stress stimuli. Collectively, these results suggest that both G3BP1 and G3BP2 play a role in the formation of SGs in various human cells and thereby recovery from these cellular stresses.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Finland 1 1%
Japan 1 1%
Netherlands 1 1%
Canada 1 1%
Unknown 81 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 22%
Student > Master 18 21%
Student > Bachelor 14 16%
Researcher 13 15%
Student > Doctoral Student 6 7%
Other 17 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 41 47%
Biochemistry, Genetics and Molecular Biology 25 29%
Unspecified 6 7%
Medicine and Dentistry 6 7%
Neuroscience 5 6%
Other 4 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2017.
All research outputs
#3,097,781
of 12,348,126 outputs
Outputs from Genes to Cells
#166
of 944 outputs
Outputs of similar age
#68,865
of 278,251 outputs
Outputs of similar age from Genes to Cells
#3
of 68 outputs
Altmetric has tracked 12,348,126 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 944 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,251 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.