Title |
Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer
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Published in |
Journal of Translational Medicine, November 2012
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DOI | 10.1186/1479-5876-10-226 |
Pubmed ID | |
Authors |
Aleksandra Markiewicz, Tomasz Ahrends, Marzena Wełnicka-Jaśkiewicz, Barbara Seroczyńska, Jarosław Skokowski, Janusz Jaśkiewicz, Jolanta Szade, Wojciech Biernat, Anna J Żaczek |
Abstract |
Breast cancers are phenotypically and genotypically heterogeneous tumors containing multiple cancer cell populations with various metastatic potential. Aggressive tumor cell subpopulations might more easily be captured in lymph nodes metastases (LNM) than in primary tumors (PT). We evaluated mRNA and protein levels of master EMT regulators: TWIST1, SNAIL and SLUG, protein levels of EMT-related markers: E-cadherin, vimentin, and expression of classical breast cancer receptors: HER2, ER and PgR in PT and corresponding LNM. The results were correlated with clinicopathological data and patients outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
Brazil | 2 | 5% |
Serbia | 1 | 2% |
Unknown | 37 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 19% |
Student > Doctoral Student | 6 | 14% |
Student > Master | 6 | 14% |
Student > Bachelor | 5 | 12% |
Other | 5 | 12% |
Other | 5 | 12% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 36% |
Agricultural and Biological Sciences | 13 | 31% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Chemical Engineering | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Other | 1 | 2% |
Unknown | 9 | 21% |