↓ Skip to main content

Open-label add-on treatment trial of minocycline in fragile X syndrome

Overview of attention for article published in BMC Neurology, October 2010
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

dimensions_citation
156 Dimensions

Readers on

mendeley
123 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Open-label add-on treatment trial of minocycline in fragile X syndrome
Published in
BMC Neurology, October 2010
DOI 10.1186/1471-2377-10-91
Pubmed ID
Authors

Carlo Paribello, Leeping Tao, Anthony Folino, Elizabeth Berry-Kravis, Michael Tranfaglia, Iryna M Ethell, Douglas W Ethell

Abstract

Fragile X syndrome (FXS) is a disorder characterized by a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socio-emotional problems. It is hypothesized that the absence of the fragile X mental retardation protein (FMRP) leads to higher levels of matrix metallo-proteinase-9 activity (MMP-9) in the brain. Minocycline inhibits MMP-9 activity, and alleviates behavioural and synapse abnormalities in fmr1 knockout mice, an established model for FXS. This open-label add-on pilot trial was conducted to evaluate safety and efficacy of minocycline in treating behavioural abnormalities that occur in humans with FXS.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 3 2%
United States 3 2%
United Kingdom 1 <1%
Australia 1 <1%
Russia 1 <1%
Colombia 1 <1%
Unknown 113 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 20%
Researcher 22 18%
Student > Master 15 12%
Student > Doctoral Student 14 11%
Student > Bachelor 12 10%
Other 36 29%
Readers by discipline Count As %
Medicine and Dentistry 31 25%
Agricultural and Biological Sciences 29 24%
Unspecified 19 15%
Psychology 19 15%
Neuroscience 12 10%
Other 13 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2013.
All research outputs
#1,605,190
of 11,618,793 outputs
Outputs from BMC Neurology
#220
of 1,331 outputs
Outputs of similar age
#48,371
of 304,301 outputs
Outputs of similar age from BMC Neurology
#13
of 61 outputs
Altmetric has tracked 11,618,793 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,331 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,301 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.