Title |
Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines
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Published in |
Virology Journal, January 2013
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DOI | 10.1186/1743-422x-10-1 |
Pubmed ID | |
Authors |
Maja Malkowska, Katarzyna Kokoszynska, Magdalena Dymecka, Leszek Rychlewski, Lucjan S Wyrwicz |
Abstract |
Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Belgium | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 33% |
Student > Master | 3 | 20% |
Student > Doctoral Student | 2 | 13% |
Researcher | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Other | 2 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 40% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Immunology and Microbiology | 1 | 7% |
Other | 2 | 13% |